iCRT 14 ( iCRT14; iCRT-14; iCRT 14; Wnt inhibitor )

产品货号. M18982 CAS No. 677331-12-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

iCRT 14
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT)(IC50= 40.3 nM in assays of Wnt pathway activity).
产品描述

iCRT14 is a potent inhibitor of β-catenin-responsive transcription (CRT) that inhibits Wnt signaling in a reporter assay in vitro (IC50 = 40.3 nM). It inhibits the interaction between β-catenin and T cell factor 4 (Tcf4) in quantitative reporter assays of β-catenin/Tcf4 binding (Ki = 53.51 μM).
同义词

iCRT14; iCRT-14; iCRT 14; Wnt inhibitor
通路

Others
靶点

Other Targets
受体

Wnt
研究领域

Cancer
适应症

——

CAS Number

677331-12-3
分子量

375.44
分子式

C21H17N3O2S
纯度

98%
溶解度

DMSO : ≥ 29 mg/mL; 77.24 mM
SMILES

O=C4S\C(=C/c2cc(C)n(c1cccnc1)c2C)C(=O)N4c3ccccc3
化学全称

5-[[2,5-dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-3-phenyl-2,4-thiazolidinedione

1.Gonsalves FC, et al. Proc Natl Acad Sci USA. 2011 Apr 12;108(15):5954-63.

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